CBAS® Heparin-Coated Catheters for Laboratory Animals

Consider using heparin-coated catheters for improved patency in long-duration studies, blood sampling applications and when working with high value animals.

Carmeda BioActive Surface (CBAS®) is the product of Carmeda AB, a W.L. Gore company. Carmeda has an extensive bibliography of CBAS applications, particularly in human-use devices, including central venous catheters, coronary stents, ventricular assist devices, extracorporeal blood circuits, blood sampling devices, and vascular grafts. CBAS is used to coat devices from J&J, Medtronic, and Gore. In lab animal research, CBAS-coated catheters are used for arterial and venous access. Also, CBAS provides dramatic improvement in catheter patency for chronic lymphatic access.

CBAS is the most respected thromboresistant coating available in the human-use medical device industry. It is under license to Solomon Scientific for use in laboratory animal research applications.

Rat Data - Published in Comparative Medicine (June 2002)

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Catheter Type Median Patency Culture-Positive* Uncoated 17.5 days 3 of 8 CBAS® coated 30 days (study end) 0 of 9 * Blood culture positive for Staphylococcus intermedius or S. aureus

How It Works

CBAS is a patented process for applying heparin to the surfaces of biomaterials. Unlike TDMAC heparin, the CBAS covalent bonds last several months. The "active sequence" of the heparin molecule serves to halt the clotting cascade. The endothelial lining of blood vessels contains a heparin-like substance which performs like CBAS. The novel aspect of CBAS is that the active sequence remains available over and over to bind with antithrombin. No other coating can achieve this long-term function. Download the PDF below for additional information on CBAS function.

Reduces Infection

Human clinical studies using CBAS and other heparin coatings document a clear anti-infective benefit from heparin coatings. While heparin is not an antimicrobial per se, it does remove the blood nidus for microorganisms thereby minimizing the nutrients and binding sites for many of the unfavorable blood proteins. Appelgren et al demonstrated a 50% reduction in infections from CBAS coated catheters in humans. Visit www.carmeda.com for additional information and complete CBAS bibliography.

CBAS-coated polyurethane catheters are clear with rounded tips, two moveable suture bulbs and attachment sleeve (no depth markings). Note that the 2Fr size has been discontinued. In addition to the standard configurations, CBAS catheters can be customized.

Individually packaged and EtO sterilized. Minimum order quantity is 5 pieces.

U.S. Pricing

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catheters information [PDF]